Introduction

Research studies have evaluated the promising effects of celery seed extract, particularly its active compound 3-n-butylphthalide (3nB),in managing inflammation, among other health benefits. Its anti-inflammatory and antioxidant activities suggest the potential benefits in reducing inflammation which is associated with physical activity.

• 3nB celery seed extract is standardized 85% of total phthalides of which 3n Butylphthalide and sedanenolide are the predominant compounds
• 3nB celery seed extract is fully extracted to maximize bioavailability with a concentrated amount of phthalides purified to 85%
• 3nB celery seed extract supports increased mobility in patients with chronic joint pain & inflammation
• 3nB celery seed extract has the highest phthalide content and clinically proven to significantly reduce pain and increase mobility
• Clinical study on the 3nB celery seed extract standardized to 85% of total phthalides showed a statistically significant decrease in both systolic (SBP) and diastolic blood pressure (DBP) compared to baseline measurements (1).

Research studies supporting the beneficial effects of 3nB celery seed extract and anti-inflammatory effects

• Pectic polysaccharides like apiuman found in celery stalks could contribute to the anti-inflammatory effects (2).

• A combination of pilates training and celery seed supplementation for 8 weeks can be beneficial in controlling inflammatory process in patients with rheumatoid arthritis​ (3).

• Studies in rats have shown that celery seed extracts could be beneficial in treating gout symptoms, due to its anti-inflammatory and antioxidative properties (4).

• Celery supplements can prevent the development of bone diseases in overweight middle-aged women as observed in a clinical study (5).
• 3nB has been found to have antihypertensive properties, making it beneficial for those struggling with high blood pressure, a condition often associated with inflammation. In a mice study, celery seed extract helped lower blood pressure in hypertensive rats (6).
• In a study, it was shown that exposing certain cells to 3nB reduced both oxidative stress and pro-inflammatory pathways indicating that celery seed may help reduce gout-related inflammation (7).
• 3nB might be beneficial for protection against post-ischemic neuronal injuries in rats (8).

• Animal studies have indicated that 3nB has vasorelaxant effect, is hypotensive, and reduce inflammation following ischemic brain injury in rats (9, 10).
• Extracts from celery seeds showed gastroprotective effects against gastric injury from various NSAIDs in chronically inflammed rats (11).

These findings indicate that 3nB has the potential to reduce inflammation by modulating various inflammatory markers and signaling pathways.

References

1. Madhavi DL. A pilot study to evaluate the antihypertensive effect of a celery extract in mild to moderate hypertensive patients (https://www.naturalmedicinejournal.com/journal/pilot-study-evaluate-antihypertensive-effect-celery-extract-mild-moderate)

2. Ovodova RG et al, Chemical composition and anti-inflammatory activity of pectic polysaccharide isolated from celery stalks. Food Chemistry.
   (2); 2009; 610-615.

3. Reyhani SS et al. The effects of 8 weeks of pilates training and celery seeds powder supplementation on serum CRP level and ESR in middle aged women with rheumatoid arthritis.J Appl Health Stud Sport Physiol. 2020;7:1-10.

4. Shaopeng L et al, Anti‐gouty arthritis and anti‐hyperuricemia properties of celery seed extracts in rodent models. Molecular Medicine. 2019;20; 4623-4633.

5. Sherzai et al. The effect of Celery on biomarkers bone in middle aged women.

Indian Journal of Fundamental and Applied Life Sciences ISSN: 2231-6345 2015; 5(2).18-27.

6. Moghadam et al. Antihypertensive effect of celery seed on rat blood pressure in chronic administration. J Med Food 2013;16(6):558-63.

7. Liu et al. DL-3-n-butylphthalide protects endothelial cells against advanced glycation end product-induced injury by attenuating oxidative stress and inflammation responses. Exp Ther Med. 2017;14(3): 2241–2248.

8. Hu D, Huang XX and Feng YP: Effect of dl-3-n-butylphthalide (NBP) on purine metabolites in striatum extracellular fluid in four-vessel occlusion rats. Yao Hsueh Hsueh 1996; 31:13-7.

9. Tsi D and Tan BKH. Cardiovascular pharmacology of 3-n-butylphthalide in spontaneously hypertensive rats, Phytother. Res.1997. 11: 576-582.

10. Xu, H.L. and Feng, Y.P., Inhibitory effects of chiral 3-n-butylphthalide on inflammation following focal ischemic brain injury in rats, Acta Pharmacol. Sin. 2000. 21:433-438.

11. Whitehouse et al. NSAID gastropathy: Prevention by celery seed extracts in disease stressed rats, Inflammopharmacol. 2001;9: 201-209.