Product Focus
MicroActive MelatoninSR
BioActives just completed a clinical study of their MicroActive MelatoninSR formulation. The study indicated that the formulation supported a natural sleep cycle, helping to fall asleep and stay asleep, waking up in 7 to 8 hours. Further results indicated that MicroActive MelatoninSR supported melatonin levels in the cycle starting at 1 hour and falling off in 7 hours. The immediate release Melatonin, by comparison, reached the threshold level in 30 minutes, with a sharp peak at 1 hour falling off in 4.5 hours prior to the a natural 7 yo 8 hours.
MicroActive MelatoninSR lengthened the release of melatonin and also prolonged the half-life compared to the immediate release product. In the initial phase (0 -3hr), the plasma concentration of melatonin with the MicroActive MelatoninSR was lower as compared to that with the immediate release Melatonin. However, in the delayed phase (4–8 hr.), the plasma concentration of MicroActive MelatoninSR was higher as compared to that of immediate release Melatonin. MicroActive MelatoninSR did not show a sharp peak concentration but showed a gradual increase in the plasma levels with a maximum plasma level around 4 hours and a gradual decrease by 8 hours, which supports staying asleep.
MicroActive MelatoninSR lengthened the release of melatonin and also prolonged the half-life compared to the immediate release product. In the initial phase (0 -3hr), the plasma concentration of melatonin with the MicroActive MelatoninSR was lower as compared to that with the immediate release Melatonin. However, in the delayed phase (4–8 hr.), the plasma concentration of MicroActive MelatoninSR was higher as compared to that of immediate release Melatonin. MicroActive MelatoninSR did not show a sharp peak concentration but showed a gradual increase in the plasma levels with a maximum plasma level around 4 hours and a gradual decrease by 8 hours, which supports staying asleep.
MicroActive Curcumin Supports Brain Health and Mental Acuity
A growing body of literature suggests that the minor components in curcumin, namely Bisdemethoxycurcumin (BDMC) and demethoxycurcumin (DMC) may protect against neurodegenerative diseases such as Alzheimer’s and Parkinson’s and play a role in supporting mental acuity.
- MicroActive Curcumin, A more bioavailable and sustained release formulation of curcumin is 9.7 times more bioavailable than regular curcumin [1].
- In a single dose 10 subject study, all the participants showed better absorption of the curcuminoids from MicroActive Curcumin compared to regular curcumin [1].
- MicroActive Curcumin significantly increased the plasma levels of the minor curcuminoids especially BDMC [1] .
3-n-butylphthalide (3nB) and anti-inflammatory effects
Research studies have evaluated the promising effects of celery seed extract, particularly its active compound 3-n-butylphthalide (3nB),in managing inflammation, among other health benefits. Its anti-inflammatory and antioxidant activities suggest the potential benefits in reducing inflammation which is associated with physical activity.
- 3nB celery seed extract is standardized 85% of total phthalides of which 3n Butylphthalide and sedanenolide are the predominant compounds
- 3nB celery seed extract is fully extracted to maximize bioavailability with a concentrated amount of phthalides purified to 85%
- 3nB celery seed extract supports increased mobility in patients with chronic joint pain & inflammation
- 3nB celery seed extract has the highest phthalide content and clinically proven to significantly reduce pain and increase mobility
- Clinical study on the 3nB celery seed extract standardized to 85% of total phthalides showed a statistically significant decrease in both systolic (SBP) and diastolic blood pressure (DBP) compared to baseline measurements (1).